Job Description

Senior Scientist- Translational Medicine

Location: Cambridge, MA

Summary:

Our client is a publicly traded Boston based precision medicine company searching for a Translational Medicine leader to play an integral role in advancing their oncology pipeline which is at various development stages. With a pipeline drug count of >20 and > 15 ongoing trials this is an opportunity to work at the forefront of one of Boston's most high profile Translational Medicine groups.

We're seeking a Senior Scientist who is highly motivated, scientifically creative, and collaborative to work in a fast-paced workplace with a cross-functional team. You will be a highly driven scientist who is committed to biomarker discovery, clinical biomarker development, implementation, and interpretation in order to enhance their oncology pipeline. You will be in charge of developing and implementing comprehensive biomarker strategies using cutting-edge technologies. The ideal candidate will be a sharp thinker. Someone with strong knowledge of cancer biology, molecular pathways, who's experience included translational research related to biomarker development and patient selection.

Objectives and Responsibilities:

• Define and implement translational and biomarker methods for clinical-stage oncology programmes, with a focus on MOA, target engagement, establishing PK/PD/efficacy relationships and patient selection strategies.
• Ensure that discovery, pre-clinical, and clinical biomarker programmes are designed and implemented efficiently and in accordance with the program's strategic needs.
• Experiment design and/or supervision, lab-based research, data analysis, data integration, and data storage are all tasks that must be completed and/or supervised.
• Conduct, optimize, and troubleshoot assays independently (whether in-house or CRO).
• Manage external biomarker analysis at speciality CROs, which includes experimental design, validation, qualification, budgeting, schedules, and quality and execution control during trial execution.
• Help to create clinical protocols, laboratory manuals, regulatory filings, abstracts, and publications.
• Analyze and deliver integrated scientific results and programme strategy implications to internal and external stakeholders.
• To guarantee successful clinic execution, effectively collaborate across internal functions such as discovery, translational, clinical pharmacology, clinical development, data administration, and regulatory affairs.
• To enable exploratory biomarkers, evaluate new technologies and collaborate with external collaborators.

Requirements:

• PhD in oncology, or related discipline
• Relevant post-doctoral training and/or 4/6+ years of relevant experience in an industry setting.
• Knowledge of clinically relevant biomarker methods across a variety of technology platforms is required.
• Worked with central laboratories and contract research organisations to enable specialised biomarker analyses.
• Experience working in a GxP setting with a quality focus
• Strong interpersonal and communication skills, as well as a desire to work in a fast-paced environment characterised by challenging and rigorous science and innovative thinking are required.
• Excellent documentation and organisational skills, as well as familiarity with CDx and personalised medicine development, are also required.
• Prior experience working with translational assays and data is preferred.
• Extensive familiarity with cutting-edge assays and standard software analytical tools such as xlsx, Prism, and others.
• Experience with PK/PD/efficacy connections and giving PD readouts via western and plate-based assays for in vitro testing

If interested please contact eoin.whittaker@skillsalliance.com