research scientist

But why work for us?

• You will work from modern, state-of-the-art laboratories and solve challenging problems for our clients.
• Our global clients range from big pharma and biotechs to academic and charitable organisations. Teamwork and communication are as important as the science we do – how we interact and communicate with our clients is part of our success.
• We foster a culture of collective responsibility and communal working. If you’re challenged by a problem, your project team, department, and the company will support you to find a solution.
• We want you to have a long and rewarding career at Sygnature. We can offer a challenging, stimulating and fulfilling role in a sociable team that’s passionate about drug discovery. It’s an extremely motivating and humbling experience to discover a lifesaving drug.

The opportunity:

• You will provide bioanalytical support to discovery studies to understand the pharmacokinetics (PK) and absorption, metabolism, distribution, and excretion (ADME) of novel chemical entities.
• Where appropriate, you will represent DMPK as the subject matter expert on Sygnature Discovery’s client project teams.
• You will aid in the analysis, interpretation, integration, and reporting of discovery DMPK bioanalytical data and further processing of these data by non-compartmental analysis to determine pharmacokinetic parameters.
• You will independently apply bioanalytical support to DMPK assays, attend scientific meetings, and keep abreast of DMPK literature related to bioanalytical science.
• Where appropriate, you will assist junior level scientists with bioanalytical experimental design and troubleshooting.

Key requirements:

• B.Sc., M.Sc. and/or Ph.D. in pharmaceutical sciences, Chemistry, Biochemistry, or related disciplines with knowledge of bioanalytical LC-MS approaches in respect of method optimisation and development for novel chemical entities.
• Proficient in operating and trouble-shooting LC-MS/MS systems and HRMS systems.
• Experience of performing bioanalytical assays including blood/plasma, urine, or tissues by various sample preparation approaches.
• Ideally experience of generation of NCA pharmacokinetic parameters and some knowledge of absorption, distribution, drug metabolism and pharmacokinetics.
• Some CRO, biotech and/or pharmaceutical industry experience in discovery bioanalytical DMPK.
• Outstanding written and verbal communication skills.